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Metoclopramide is excreted in human milkCaution should be exercised when metoclopramide is administered to a nursing mother.

Metoclopramide undergoes minimal hepatic metabolismexcept for simple conjugationIts safe use has been described in patients with advanced liver disease whose renal function was normal.

A few cases of neutropenialeukopeniaor agranulocytosisgenerally without clear-cut relationship to metoclopramideMethemoglobinemiain adults and especially with overdosage in neonatessee OVERDOSESulfhemoglobinemia in adults.

NOTEParenteral drug products should be inspected visually for particulate matter and discoloration prior to administrationwhenever solution and container permit.

Metoclopramide stimulates motility of the upper gastrointestinal tract without stimulating gastricbiliaryor pancreatic secretionsIts mode of action is unclearIt seems to sensitize tissues to the action of acetylcholineThe effect of metoclopramide on motility is not dependent on intact vagal innervationbut it can be abolished by anticholinergic drugs.

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